TauroLock™-U25.000
Proven Protection for Catheter Care
Triple-Action Protection for High-Risk Catheters
TauroLock™-U25.000 is an antimicrobial and fibrinolytic citrate catheter lock solution, combining taurolidine, 4% citrate, and urokinase (25,000 IU). This triple-action formulation provides enhanced protection against catheter-related complications by helping to prevent infection, maintain line patency and reduce the need for thrombolytic rescue therapies. Each 5 mL dose is reconstituted using one ampoule (taurolidine + citrate) and one vial of lyophilised urokinase. The solution is instilled into the catheter between treatments to lock the line.
TauroLock™-U25.000 is particularly suited for patients with a history of catheter occlusion, those transitioning from alteplase, or where line salvage and ongoing maintenance are critical. While not intended as treatment for occlusions, it is generally recommended as a prophylactic lock for the prevention of infection and fibrin build-up.
Routine use has been associated with significant cost savings in medical supplies budgets, dramatically reducing the need for alteplase, catheter replacements, and unplanned hospital admissions.
More Information
TauroLock™-U25.000
Available in:
Pack size: 5 ampoules + 5 vials (TP-05)
Each dose contains:
- 1 x 5 mL glass ampoule (taurolidine + 4% citrate)
- 1 x vial of freeze-dried urokinase (25,000 IU)
Key Benefits of TauroLock™-U25.000
Maintenance of Patency
Urokinase actively dissolves fibrin clots, while taurolidine and citrate help prevent thrombus formation and microbial-induced occlusion. This triple-mechanism lock supports consistent catheter function and helps reduce the risk of line blockage over time.
Effective Infection Prevention
Taurolidine delivers broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria (including MRSA and VRE), as well as fungi such as Candida. It reduces microbial colonisation and eliminates pathogens before biofilm can develop.
Prevention of Biofilm Formation and Eradication
Taurolidine and citrate work synergistically to prevent the formation of microbial biofilm and disrupt its extracellular matrix. Urokinase contributes by dissolving early fibrin deposits that often form the foundation for biofilm development. This combined mechanism helps ensure the catheter lumen remains free of microbial build-up and blockage, supporting long-term catheter function in high-risk patients.
Reduced Risk of Complications
TauroLock™-U25.000 does not contain antibiotics, thereby reducing the risk of antimicrobial resistance. Its components are non-toxic and well-tolerated, making it suitable for long-term prophylactic use across a range of high-risk clinical settings including dialysis, oncology, parenteral nutrition, and intensive care.
To explore the full benefits of TauroLock™-U25.000 and how it can support high-risk catheter management, download the product brochure or visit the TauroPharm website for more information.
For a customised product education session or to discuss catheter-related issues, contact Prima MediPharm today. We’re here to offer expert guidance with your questions and help you place your order.